Sunday, October 18, 2009

transport through cell memebrane -cell transport-4th chapter-btechbiotechnology-cellbiology-2-1-jntu

The cell is bound by an outer membrane that, in accord with the fluid mosaic model, is comprised of a phospholipid lipid bilayer with proteins—molecules that also act as receptor sites—interspersed within the phospholipid bilayer. Varieties of channels exist within the membrane. There are a number of internal cellular membranes that partially partition the intercellular matrix, and that ultimately become continuous with the nuclear membrane.

There are three principal mechanisms of outer cellular membrane transport (i.e., means by which molecules can pass through the boundary cellular membrane). The transport mechanisms are passive, or gradient diffusion, facilitated diffusion, and active transport.

Diffusion is a process in which the random motions of molecules or other particles result in a net movement from a region of high concentration to a region of lower concentration. A familiar example of diffusion is the dissemination of floral perfumes from a bouquet to all parts of the motionless air of a room. The rate of flow of the diffusing substance is proportional to the concentration gradient for a given direction of diffusion. Thus, if the concentration of the diffusing substance is very high at the source, and is diffusing in a direction where little or none is found, the diffusion rate will be maximized. Several substances may diffuse more or less independently and simultaneously within a space or volume of liquid. Because lightweight molecules have higher average speeds than heavy molecules at the same temperature, they also tend to diffuse more rapidly. Molecules of the same weight move more rapidly at higher temperatures, increasing the rate of diffusion as the temperature rises.

Driven by concentration gradients, diffusion in the cell usually takes place through channels or pores lined by proteins. Size and electrical charge may inhibit or prohibit the passage of certain molecules or electrolytes (e.g., sodium, potassium, etc.).

Osmosis describes diffusion of water across cell membranes. Although water is a polar molecule (i.e., has overall partially positive and negative charges separated by its molecular structure), transmembrane proteins form hydrophilic (water loving) channels to through which water molecules may move.

Facilitated diffusion is the diffusion of a substance not moving against a concentration gradient (i.e., from a region of low concentration to high concentration) but which require the assistance of other molecules. These are not considered to be energetic reactions (i.e., energy in the form of use of adenosine triphosphate molecules (ATP) is not required. The facilitation or assistance—usually in physically turning or orienting a molecule so that it may more easily pass through a membrane—may be by other molecules undergoing their own random motion.

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