Saturday, August 22, 2009

deoxyribozymes as endonucleases

Better approaches for manipulating DNA in the laboratory may soon be possible with newly discovered deoxyribozymes that are capable of cleaving single-stranded DNA, according to researchers at the University of Illinois. The deoxyribozymes accomplish the DNA cleavage with the sequence-selectivity and site-selectivity required for a practical catalyst.

Dr. Silverman explains why he finds it intriguing that the novel deoxyribozymes require two metal ions, manganese and zinc, to carry out their catalysis and talks about where further research on these catalytic DNA molecules may be headed.deoxyribozymes are now to repace endonucleases

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